Skip to main content
. 2013 Dec 23;8(12):e83247. doi: 10.1371/journal.pone.0083247

Figure 9. Ultrathin sections of L. amazonensis intracellular amastigotes.

Figure 9

Control intracellular amastigotes (A) and treated amastigotes with ITZ and POSA (B–G) were observed. (B, C) 500 nM ITZ; (D) 1 µM ITZ; (E–G) 6 µM POSA. Different ultrastructural alterations were observed: mitochondrial swelling (B, D); detachment of the plasma membrane (B, arrowhead); presence of a large megasome (C, black asterisk), lipid bodies (D, E, G, white asterisks) and many vacuoles in the cytoplasm (D, E, G); changes in kinetoplast structure (C, E); and a cell with an empty parasitophorous vacuole (PV) (G). f, flagellum; m, mitochondrion; N: nucleus; PV: parasitophorous vacuole, A: autophagosome, k: kinetoplast.