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. 2013 Dec 23;8(12):e85302. doi: 10.1371/journal.pone.0085302

Figure 6. Restoration of viral control and LCMV-specific CD8+ and CD4+ T cell responses by IFN-α supplementation.

Figure 6

(A) Spleen virus titer quantified 2 days after LCMV-WE infection of 2-week-old mice supplemented or not with 10,000U of recombinant mouse IFN-α given i.p. at 4h, 8h and 12h after infection. One of two representative experiments is shown. *, p<0.05. (B-D) One injection of long-lasting human recombinant pegylated IFN-α 2a was added 6h after LCMV infection. Analyses were performed 12 days later. (B) % of spleen LCMVnp118-126-specific CD8+ T cells. One of two representative experiments is shown. *, p<0.05. (C) % of LCMVnp6-20-specific IFN-γ, IL-2 and TNF-α secreting CD44+CD4+ T cells. Percentages obtained in medium controls were subtracted. One of two representative experiments is shown. *, p<0.05. (D) Splenic virus titers. One of two representative experiments is shown. *, p<0.05.