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. 2013 Dec 23;8(12):e84442. doi: 10.1371/journal.pone.0084442

Figure 2. Thiamet-G rescued upper-airway breathing defects of Tau.P301L mice.

Figure 2

Dual-chamber plethysmography, schematically represented in the upper panel, was performed as described [25,26]. Treatment of Tau.P301L mice for 3 days with Thiamet-G in the drinking water (2.5 mg/ml) in the home-cage, significantly improved their breathing deficit in normocapnia (panel A) and in hypercapnia (panel B). Of note, the improved breathing efficacy was nearly normalized to that of age-matched wild-type mice (see text for details). Also note that the positive effect was most significant for older Tau.P301L mice. Statistical analysis by ANOVA: *p<0.05, **p<0.01.