Skip to main content
. 2013 Dec 23;8(12):e82649. doi: 10.1371/journal.pone.0082649

Figure 2. Conventional MRI, DWI and DCE MRI at different time points.

Figure 2

(a) Representative T1WI, T2WI, CE-T1WI, DWI-derived ADC map and DCE MRI-derived MSI and PEI maps were enumerated in the figures. Twenty four hours after CA4P treatment, the enhancement of tumor was sharply decreased but the ADC map was similar to that at baseline. An obvious hyperintense center was noticed at day 4 and day 8 with only a thin hypointense peritumoral rim. On T1CE images, at same time, there was still no enhancement in the center, but a progressively enhanced rim was observed. At day 12, inhomogeneous enhancement was seen on the entire tumor with irregular nodules from the rim towards the center on both CE-T1WI and ADC map. The blood perfusion of tumor sharply decreased at 24 h because the shut-down of the tumor vessels on both MSI and PSI maps at 24 h, and gradual decrease was also observed at afterward time points. However, a recovery of blood perfusion on MSI map at 4 d might be due to the re-growth of tumor cells on the periphery. (b, c) Quantitative MSI (b) and PEI (c) values of tumor and liver were showed and compared with bar charts. (d) Quantitative ADC values of entire tumor, center or periphery of tumor, and liver were showed and compared with a bar chart. *The values had statistical changes compared with those at previous time point (P<0.05).