Table 1. Summary of GWAS and replication studies.

SNP		Case				Control				MAF
locus	Study	TT	TC	CC		TT	TC	CC		Case	Control	OR	(95%CI)a	P b	P het c
rs9275572	GWAS	96	217	168		366	1317	1280		0.425	0.346	0.71	(0.62-0.82)	2.62E-06
HLA-DQB1	1st replication	634	2049	1673		119	474	519		0.381	0.320	0.77	(0.69-0.85)	1.40E-07
	2nd replication	206	695	477		3279	11284	10260		0.402	0.359	0.84	(0.77-0.90)	7.63E-06
	Combined GWAS and 1st replication studyd											0.75	(0.69-0.81)	2.04E-12	4.25E-01
	Combined all studiese											0.79	(0.75-0.84)	3.59E-16	1.13E-01

MAF; minor allele frequency, OR; odds ratio, CI; confidence interval.

Odds ratios and P values for independence test were calculated by the Mantel-Haenszel method.

^aOdds ratios of protective allele (C) from two-by-two allele frequency table. ^b P value of Cochran-Armitage trend test.

^cResult of Breslow-Day test. ^dMeta-analysis of GWAS and 1st replication study. ^eMeta-analysis of all three studies.