Table 2. Effect of common HLA-DQA1 and HLA-DQB1 haplotypes on chronic hepatitis C.
|
Case
|
Control
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| n | freq.(%) | n | freq.(%) | ORa | (95%CI) | Pb | |||
| DQA1 | *0101 | 304 | 14.3 | 320 | 14.4 | 0.99 | (0.84-1.18) | 9.53E-01 | |
| *0102 | 302 | 14.2 | 263 | 11.8 | 1.24 | (1.04-1.48) | 1.84E-02 | ||
| *0103 | 445 | 21.0 | 423 | 19.0 | 1.13 | (0.97-1.31) | 1.08E-01 | ||
| *0301 | 830 | 39.1 | 924 | 41.5 | 0.90 | (0.80-1.02) | 1.02E-01 | ||
| *0401 | 65 | 3.1 | 58 | 2.6 | 1.18 | (0.82-1.69) | 3.66E-01 | ||
| *0501 | 138 | 6.5 | 177 | 8.0 | 0.80 | (0.64-1.01) | 6.44E-02 | ||
| *0601 | 30 | 1.4 | 49 | 2.2 | 0.64 | (0.40-1.01) | 5.15E-02 | ||
| DQB1 | *0301 | 181 | 8.4 | 207 | 9.6 | 0.86 | (0.70-1.06) | 1.69E-01 | |
| *0302 | 220 | 10.2 | 245 | 11.4 | 0.89 | (0.73-1.08) | 2.24E-01 | ||
| *0303 | 272 | 12.6 | 372 | 17.3 | 0.69 | (0.59-0.82) | 2.05E-05 | ||
| *0401 | 305 | 14.2 | 282 | 13.1 | 1.10 | (0.92-1.30) | 3.01E-01 | ||
| *0402 | 114 | 5.3 | 84 | 3.9 | 1.38 | (1.03-1.84) | 2.86E-02 | ||
| *0501 | 147 | 6.8 | 168 | 7.8 | 0.87 | (0.69-1.09) | 2.22E-01 | ||
| *0502 | 59 | 2.7 | 61 | 2.8 | 0.97 | (0.67-1.39) | 8.57E-01 | ||
| *0503 | 116 | 5.4 | 78 | 3.6 | 1.52 | (1.13-2.03) | 5.14E-03 | ||
| *0601 | 444 | 20.6 | 409 | 19.0 | 1.11 | (0.95-1.29) | 1.76E-01 | ||
| *0602 | 155 | 7.2 | 128 | 5.9 | 1.23 | (0.96-1.57) | 9.52E-02 | ||
| *0604 | 119 | 5.5 | 98 | 4.5 | 1.23 | (0.93-1.62) | 1.42E-01 | ||
aOdds ratios of haplotype from two-by-two frequency table. b P value of chi-squared test.
Only alleles with frequencies of more than 1% were shown.