Table 3. Case-control association analysis of 5 variants using 1,074 chronic hepatitis C cases and 1,073 healthy controls.
Allele |
Case
|
Control
|
HWE-pa
|
Protective AF
|
|||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | [1/2] | 11 | 12 | 22 | 11 | 12 | 22 | Case | Control | Case | Control | ORb | (95%CI) | P c | |||
rs8099917 | G/T | 15 | 235 | 824 | 10 | 188 | 875 | 0.704 | 0.978 | 0.877 | 0.903 | 0.76 | (0.63-0.92) | 5.53E-03 | |||
rs12979860 | T/C | 16 | 244 | 814 | 11 | 194 | 868 | 0.637 | 0.965 | 0.872 | 0.899 | 0.76 | (0.63-0.92) | 4.08E-03 | |||
ss469415590 | ΔG/TT | 16 | 244 | 814 | 11 | 192 | 870 | 0.637 | 0.911 | 0.872 | 0.900 | 0.75 | (0.62-0.91) | 2.96E-03 | |||
rs9275572 | T/C | 166 | 492 | 416 | 112 | 459 | 502 | 0.305 | 0.641 | 0.616 | 0.682 | 0.75 | (0.66-0.85) | 9.64E-06 | |||
rs1130380 | C/G | 120 | 433 | 521 | 172 | 478 | 423 | 0.039 | 0.060 | 0.313 | 0.383 | 0.73 | (0.65-0.83) | 3.38E-06 | |||
AF; allele frequency, OR; odds ratio, CI; confidence interval.
a P value of Hardy-Weinberg equilibrium test. bOdds ratio of protective allele. c P value of Cochran-Armitage trend test.