Table 4. Effect of HLA-DQB1*03 and rs9275572 on the susceptibility of chronic hepatitis C stratified by genotype of ss469415590.
| ss469415590 | Allele | Case |
Control |
Protective AF |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [1/2] | 11 | 12 | 22 | 11 | 12 | 22 | Case | Control | OR | (95%CI)a | P b | P het c | |||
| TT/TT | HLA-DQB1 | 80 | 330 | 404 | 137 | 386 | 347 | 0.301 | 0.379 | 0.70 | (0.61-0.81) | 3.09E-06 | 3.36E-01 | ||
| ΔG/TT or ΔG/ΔG | [*03 / non-*03] | 40 | 103 | 117 | 35 | 92 | 76 | 0.352 | 0.399 | 0.82 | (0.63-1.07) | 1.61E-01 | |||
| TT/TT | rs9275572 | 134 | 389 | 291 | 89 | 367 | 414 | 0.596 | 0.687 | 0.67 | (0.59-0.78) | 6.31E-08 | 2.45E-03 | ||
| ΔG/TT or ΔG/ΔG | [T / C] | 32 | 103 | 125 | 23 | 92 | 88 | 0.679 | 0.660 | 1.09 | (0.83-1.43) | 5.56E-01 | |||
AF; allele frequency, OR; odds ratio, CI; confidence interval.
aOdds ratios of protective allele from two-by-two allele frequency table. b P value of Cochran-Armitage trend test. cResult of Breslow-Day test.