Figure 4. ¹¹C-MET is superior to ¹⁸F-FET and ¹⁸F-FDG in CD138⁺-plasma cells.

CD138⁺-plasma cells were incubated with either ¹⁸F-FDG, ¹⁸F-FET or ¹¹C-MET for 60 min and intracellular radioactivity was quantified using a gamma-counter. Relative uptake of background- and decay-corrected samples was expressed as cpm per 1000 cells. Whenever possible, bone marrow samples were split and one half of the sample was incubated with ¹⁸F-FDG, the other with either ¹⁸F-FET (patients no 7, 10, 11) or ¹¹C-MET (patients no. 13, 16, 17, 18, 19, 21, 22, 26). (A) ¹⁸F-FDG, ¹⁸F-FET and ¹¹C-MET uptake by CD138⁺ PCs. Data from all samples analyzed are shown. (B) Direct comparison of ¹⁸F-FDG and ¹¹C-MET uptake in split samples. Lines indicate corresponding samples from one patient.