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. 2013 Dec 23;8(12):e82191. doi: 10.1371/journal.pone.0082191

Figure 4. Block of GABA(B) receptors prevents the depressant effect of HFS-STN conditioning on unitary test responses induced by microstimulation of single STN axons in the SNr.

Figure 4

A) Example traces to illustrate partial reversal of the HFS-STN effect on unitary EPSCs elicited with Microstim. Experiment in the presence of gabazine (15 µM). B) The plot of normalized uEPSC amplitudes against time of recording. The average value before the HFS trials is 100%. More than 10 min were allowed for the wash-in of the GABA(B) antagonist CGP55845 (1 µM). Note the alleviation of amplitude depression (B,C) and the increase in the success rate (D) in the presence of the GABA(B) blocker CGP55845. E,F) Quantification of the presynaptic parameters PPR and CV. The bars above the empty and shaded columns refer to the results of paired t-test. The asterisks above each column indicate significance levels from comparison with the Control, as tested with ANOVA. The differences between Control and respective Recovery values were not significant and are omitted in the graphs, for clarity.