Table 1. Effects of multi-unit and single-unit HFS on glutamatergic unitary synaptic responses in the SNr.
HFS type | Parameter | Control | HFS | |||||
Average | ±SE | Average | ±SE | N | %Change | p | ||
Multi-unit | FV in STN (µV) | 835,08 | 185,43 | 861,25 | 285,79 | 8 | none | ns |
FV in SNr (µV) | 673,51 | 154,31 | 589,44 | 135,59 | 9 | none | ns | |
Multi-unit | uEPSC occlusion-positive | |||||||
Amplitude (pA) | 23,26 | 3,15 | 5,88 | 1,14 | 9 | −75 | <0.001 | |
PPR | 0,84 | 0,09 | 1,36 | 0,20 | 9 | 63 | 0,022 | |
CV (%) | 53,97 | 6,07 | 179,24 | 22,18 | 9 | 232 | <0.001 | |
Success rate (%) | 86,53 | 3,57 | 33,60 | 6,75 | 9 | −61 | <0.001 | |
Multi-unit | uEPSC occlusion-negative | |||||||
Amplitude (pA) | 46,27 | 7,58 | 20,10 | 4,03 | 27 | −57 | <0.001 | |
PPR | 0,86 | 0,06 | 1,30 | 0,12 | 27 | 52 | <0.001 | |
CV (%) | 29,64 | 5,31 | 78,00 | 24,09 | 27 | 163 | 0,035 | |
Success rate (%) | 89,86 | 1,87 | 56,97 | 5,92 | 27 | −37 | <0.001 | |
Multi-unit | uEPSC occlusion-negative | |||||||
Failures excluded | ||||||||
Amplitude (pA) | 42,07 | 8,18 | 28,11 | 5,07 | 15 | −33 | 0,002 | |
PPR | 0,83 | 0,06 | 1,04 | 0,06 | 15 | 25 | 0,002 | |
CV (%) | 36,67 | 2,72 | 38,46 | 2,72 | 15 | none | ns | |
Multi-unit | uEPSC occlusion-negative | |||||||
GABA(B) block | ||||||||
Amplitude (pA) | 55,66 | 14,32 | 37,56 | 7,50 | 11 | −33 | 0,070 | |
PPR | 0,95 | 0,10 | 1,07 | 0,15 | 11 | 12 | ns | |
CV (%) | 0,51 | 0,07 | 0,84 | 0,29 | 11 | 63 | ns | |
Success rate (%) | 89,54 | 3,75 | 78,63 | 8,64 | 11 | −12 | ns | |
Single-unit | uEPSC | |||||||
Amplitude (pA) | 68,69 | 11,86 | 26,51 | 5,28 | 9 | −61 | 0,001 | |
PPR | 0,91 | 0,09 | 1,09 | 0,06 | 8 | 20 | 0,033 | |
CV (%) | 41,09 | 5,29 | 61,02 | 5,76 | 8 | 49 | 0,007 | |
Success rate (%) | 93,89 | 2,63 | 58,89 | 10,79 | 9 | −37 | 0,011 |