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. 2013 Dec 23;8(12):e85024. doi: 10.1371/journal.pone.0085024

Table 1. Availability and characteristics of the trimming tools investigated in the current work.

Tool Version Link Language Algorithm family Can work directly on gzip Can work on paired end PHRED format autodetection Works on both read ends Notes
Cutadapt 1.1 code.google.com/p/cutadapt/downloads/list Python and C Running sum yes no no no Can also remove adapters, multi-threaded
ConDeTri 2.2 code.google.com/p/condetri/ Perl Window based yes (since v2.2) yes no no
ERNE-FILTER 1.2 sourceforge.net/projects/erne/files/ C++ Running sum yes yes yes yes Can be combined with contaminant removal, multi-threaded
FASTX quality trimmer 0.0.13.2 hannonlab.cshl.edu/fastx_toolkit/download.html C++ Window based no no no no The default minimum read length parameter (-p) is set to zero
PRINSEQ 0:19:05 sourceforge.net/projects/prinseq/files/ Perl Window based no no no yes Also web interface for medium-size data
Trimmomatic 0.22 www.usadellab.org/cms/index.php?page=trimmomatic Java Window based yes yes no yes Can also remove adapters
SolexaQA 1.13 sourceforge.net/projects/solexaqa/files/ Perl Window based (Running sum with -bwa option) no no yes no Cannot specify minimum read length to keep
Sickle 1.2 github.com/ucdavis-bioinformatics/sickle C Window based yes yes no yes