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. 2013 Dec 23;8(12):e82028. doi: 10.1371/journal.pone.0082028

Table 2. Performance of glomerular filtration rate estimating equations in HIV-positive and HIV-negative participants.

Performance measure HIV-positive HIV-negative P valuea
Accuracyb (95% CI) eGFRcr 89 (83, 93) 96 (90, 99) 0.048
eGFRcys 79 (72, 85) 88 (80, 94) 0.075
eGFRcr-cys 91 (85, 94) 97 (91, 99) 0.055
P valuec eGFRcr vs. eGFRcys 0.0044 0.046 -
eGFRcr vs. eGFRcr-cys 0.51 0.71 -
eGFRcys vs eGFRcr-cys <0.0001 0.0027 -
Biasd (P25, P75) eGFRcr −1.1 (−12.4, 10.4) −8.8 (−18.0, 2.9) 0.0013
eGFRcys −16.3 (−27.8, −1.8) −12.9 (−23.8, 0.8) 0.19
eGFRcr-cys −7.2 (−19.8, 2.2) −9.7 (−19.1, 0.7) 0.56
P valuec eGFRcr vs. eGFRcys <0.0001 0.014 -
eGFRcr vs. eGFRcr-cys <0.0001 0.23 -
eGFRcys vs eGFRcr-cys <0.0001 0.0002 -
Precisione (95% CI) eGFRcr 22.8 (18.4, 27.3) 20.9 (15.1, 26.7) 0.50
eGFRcys 25.9 (22.1, 29.7) 24.5 (18.9, 30.2) 0.61
eGFRcr-cys 22.0 (18.1, 25.9) 19.8 (13.2, 26.4) 0.49
P valuec eGFRcr vs. eGFRcys 0.43 0.65 -
eGFRcr vs. eGFRcr-cys 0.43 0.27 -
eGFRcys vs eGFRcr-cys 0.12 0.10 -

CI, confidence interval; eGFRcr, eGFRcys, and eGFRcr-cys are glomerular filtration rates estimated by CKD-EPI equations using plasma creatinine, cystatin C, and both biomarkers, respectively; P25 and P75, 25th and 75th percentiles, respectively.

a

Comparisons of a single equation between the HIV-positive and HIV-negative groups. P values in bold font indicate difference is statistically significant accounting for multiple comparisons (see text).

b

Accuracy defined as percentage of estimated GFR values within 30% of measured GFR.

c

Comparisons of a different equations within the HIV-positive or HIV-negative group. P values in bold font indicate difference is statistically significant accounting for multiple comparisons (see text).

d

Bias defined as difference between estimated GFR and measured GFR (mL/min/1.73 m2).

e

Precision defined as interquartile range of bias.