Table 3. Factors associated with glomerular filtration rate estimating equation accuracya in HIV-positive and HIV-negative participants.
| Factor | HIV-positive | HIV-negative | |||
| eGFRcr | eGFRcys | eGFRcr | eGFRcys | ||
| Age, years | ≤49 | 87 (79, 93) | 80 (70, 87) | 92 (81, 98) | 94 (84, 99) |
| >49 | 90 (82, 95) | 79 (69, 87) | 100 (92, 100) | 81 (67, 91) | |
| P valueb | 0.64 | 1.00 | 0.12 | 0.064 | |
| Body mass index, kg/m2 | ≤26 | 88 (79, 93) | 77 (67, 85) | 96 (85, 99) | 84 (70, 93) |
| >26 | 90 (82, 95) | 82 (72, 89) | 96 (87, 99) | 91 (79, 97) | |
| P valueb | 0.65 | 0.47 | 1.00 | 0.38 | |
| Sex | Female | 83 (72, 91) | 78 (66, 87) | 89 (65, 99) | 100 (81, 100) |
| Male | 92 (85, 96) | 80 (71, 86) | 97 (91, 100) | 85 (75, 92) | |
| P valueb | 0.093 | 0.85 | 0.15 | 0.12 | |
| mGFR, mL/min/1.73 m2 | <90 | 80 (68, 89) | 70 (57, 82) | 94 (71, 99) | 88 (64, 99) |
| ≥90 | 93 (87, 97) | 83 (75, 89) | 96 (90, 99) | 88 (78, 94) | |
| P valueb | 0.014 | 0.051 | 0.54 | 1.00 | |
| Hepatitis C serostatus | Negative | 88 (80, 94) | 85 (76, 92) | 94 (86, 98) | 91 (82, 97) |
| Positive | 89 (81, 94) | 73 (64, 82) | 100 (88, 100) | 79 (59, 92) | |
| P valueb | 1.00 | 0.066 | 0.32 | 0.10 | |
| High-sensitivity C-reactive protein, mg/dL | ≤1.8 | 91 (83, 96) | 79 (70, 87) | 98 (89, 100) | 82 (68, 91) |
| >1.8 | 88 (79, 94) | 80 (70, 88) | 94 (83, 99) | 94 (83, 99) | |
| P valueb | 0.64 | 0.86 | 0.62 | 0.12 | |
| Percentage activated CD4 cells | ≤Medianc | 90 (82, 95) | 92 (84, 97) | 92 (80, 98) | 90 (78, 97) |
| >Medianc | 88 (79, 94) | 69 (58, 78) | 100 (93,100) | 86 (73, 94) | |
| P valueb | 0.81 | 0.0001 | 0.12 | 0.76 | |
| Percentage activated CD8 cells | ≤Mediand | 91 (83, 96) | 92 (84, 97) | 94 (83, 99) | 87 (75, 95) |
| >Mediand | 87 (78, 93) | 69 (58, 78) | 98 (89, 100) | 88 (76, 95) | |
| P valueb | 0.48 | 0.0001 | 0.36 | 1.00 | |
| Taking antiretroviral therapy | Yes | 89 (84, 94) | 82 (75, 87) | ||
| No | 81 (54, 96) | 50 (25, 75) | |||
| P valueb | 0.40 | 0.0064 | |||
| Nadir CD4, cells/mm3 | >150 | 86 (77, 92) | 80 (71, 88) | ||
| ≤150 | 92 (84, 96) | 78 (68, 86) | |||
| P valueb | 0.25 | 0.72 | |||
| Current CD4, cells/mm3 | >450 | 89 (81, 94) | 88 (80, 94) | ||
| ≤450 | 89 (80, 94) | 70 (59, 79) | |||
| P valueb | 1.00 | 0.0032 | |||
| HIV RNA, copies/ml | ≤400 | 91 (85, 95) | 87 (80, 92) | ||
| >400 | 79 (63, 90) | 50 (33, 67) | |||
| P valueb | 0.043 | <0.0001 | |||
eGFRcr and eGFRcys are glomerular filtration rates estimated by CKD-EPI equations using plasma creatinine and cystatin C, respectively; mGFR, measured glomerular filtration rate by iohexol clearance.
a
Accuracy shown as percent of estimated GFR values within 30% of measured GFR values (95% confidence interval).
b
P values in bold font indicate difference is statistically significant accounting for multiple comparisons (see text).
c
Medians 8.3% and 3.8% in HIV-positive and HIV-negative groups, respectively.
d
Medians 30.7% and 10.7% in HIV-positive and HIV-negative groups, respectively.