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. 2013 Dec 23;8(12):e83811. doi: 10.1371/journal.pone.0083811

Figure 4. Increased serum sIL-2RA correlates with lower response to IL-2.

Figure 4

PBMC and serum samples from the same blood draw were assayed for response to IL-2 as in Figure 1 and serum sIL-2RA using Luminex. All controls tested were Caucasian with no significant difference in age or gender between genotypes. Multivariable analysis was performed using linear regression and is shown in the Figure. To confirm these results we performed several additional tests. Random sampling of 80% of the data 1000 times resulted in a Pearson correlation of −0.516 and a p-value of 0.0015.Significance was also tested using a non-parametric correlation (Spearman test = −0.581, p-value of 0.0003) verifying that outliers are not the reason for statistical significance.