Table 4.
Frequencies of the genotypes and alleles of polymorphisms of FGFR genes, based on low and high international prostate symptom score (IPSS), in subjects with BPH.
| Gene | SNP | Genotype/allele | IPSS | Models | OR (95% CI) | P | |
|---|---|---|---|---|---|---|---|
| <20 n = 130 (%) |
≥20 n = 76 (%) |
||||||
| FGFR1 | rs13317 | T/T | 37 (28.5) | 36 (47.4) | Additive | 0.50 (0.32–0.79) | 0.0022 |
| T/C | 71 (54.6) | 34 (44.7) | Dominant | 0.43 (0.23–0.78) | 0.005 | ||
| C/C | 22 (16.9) | 6 (7.9) | Recessive | 0.40 (0.15–1.03) | 0.044 | ||
| T | 145 (55.8) | 106 (69.7) | 1 | ||||
| C | 115 (44.2) | 46 (30.3) | 0.55 (0.36–0.84) | 0.005 | |||
|
| |||||||
| FGFR2 | rs755793 | T/T | 113 (86.9) | 70 (92.1) | Additive | 0.53 (0.20–1.37) | 0.17 |
| T/C | 16 (12.3) | 6 (7.9) | Dominant | 0.54 (0.20–1.44) | 0.20 | ||
| C/C | 1 (0.8) | 0 (0) | Recessive | 0.00 (0.00-NA) | NA | ||
| T | 242 (93.1) | 146 (96.1) | 1 | ||||
| C | 18 (6.9) | 6 (3.9) | 0.55 (0.21–1.42) | 0.22 | |||
| rs1047100 | G/G | 107 (82.3) | 67 (88.2) | Additive | 0.60 (0.27–1.32) | 0.19 | |
| G/A | 21 (16.1) | 9 (11.8) | Dominant | 0.63 (0.27–1.45) | 0.27 | ||
| A/A | 2 (1.5) | 0 (0) | Recessive | 0.00 (0.00-NA) | NA | ||
| G | 235 (90.4) | 143 (94.1) | 1 | ||||
| A | 25 (9.6) | 9 (5.9) | 0.59 (0.27–1.30) | 0.19 | |||
| rs3135831 | C/C | 65 (50) | 36 (47.4) | Additive | 0.91 (0.60–1.39) | 0.67 | |
| C/T | 46 (35.4) | 35 (46) | Dominant | 1.17 (0.66–2.07) | 0.60 | ||
| T/T | 19 (14.6) | 5 (6.6) | Recessive | 0.41 (0.15–1.15) | 0.07 | ||
| C | 176 (67.7) | 107 (70.4) | 1 | ||||
| T | 84 (32.3) | 45 (29.6) | 0.88 (0.57–1.36) | 0.57 | |||
Bold characters represent statistically significant values (P < 0.05/4).