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. 2013 Sep 5;25(1):33–42. doi: 10.1681/ASN.2012121218

Figure 4.

Figure 4.

Angpt1 repletion ameliorates renal cortical levels of VEGF-A/VEGFR phosphorylation in diabetic mice. At 10 weeks of doxycycline (DOX) administration, VEGF-A (A) and VEGFR2-P (C) were upregulated in diabetic compared with nondiabetic mice (*P<0.01), while VEGFR2 (D) was downregulated (*P=0.02). Angpt1 repletion in diabetic mice downregulated diabetes-induced VEGFR2 phosphorylation (#P=0.04) (C) and prevented the diabetes-induced sVEGFR1 downregulation (#P=0.005) (B) (n=8–12/group in all analyses). D, diabetic; ND, nondiabetic. *indicates comparisons between nondiabetic and diabetic states; # indicates the comparisons between diabetic states without and with Angpt1 repletion.