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. Author manuscript; available in PMC: 2013 Dec 24.
Published in final edited form as: Oncogene. 2012 Dec 17;32(42):10.1038/onc.2012.530. doi: 10.1038/onc.2012.530

Figure 6.

Figure 6

pY654-β-catenin/HIF1α/Src complexes and EMT markers are increased in anti-VEGF antibody treated pancreatic tumors. (a) RIP-Tag2 tumor lysates from anti-VEGF- or control IgG-treated mice were immunoprecipitated for pY654-β-catenin and blotted for β-catenin and p-Smad2. (b) The above lysates were sequentially immunoprecipitated for two rounds of HIF1α and one round of pY654-β-catenin and blotted for β-catenin, HIF1α, and Src. (c) The above lysates were blotted for pY416-Src, Src, E-cadherin, N-cadherin, vimentin, Snail1, Twist, HIF1α, and β-actin.