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Levels of independent variables taken for optimization of metformin hydrochloride formulations.
| Independent variables | Levels used | |
|---|---|---|
| Low | High | |
| A—propylene glycol (plasticizer) (% v/v) | 15 | 20 |
| B—potassium chloride (osmogent) (mg) | 75 | 125 |
| C—fructose (osmogent) (mg) | 75 | 125 |
| Metformin.HCl (mg) | 500 | |
| Purified talc (mg) | 3 | |
| Magnesium stearate (mg) | 2 | |
