Table 3.

Experimental design summary of the metformin hydrochloride formulations.

S. No	Formulation code	Independent variables			Dependent variable
		A  Conc. of PG (% v/v)	B  Conc. of KCl (mg)	C  Conc. of Fructose (mg)	Time taken for 100% drug release (t100%)
1	F1M1	−1	+1	−1	8
2	F1M2	−1	−1	+1	16
3	F1M3	−1	+1	+1	8
4	F1M4	−1	−1	−1	10
5	F2M1	+1	+1	−1	11
6	F2M2	+1	−1	+1	18
7	F2M3	+1	+1	+1	6
8	F2M4	+1	−1	−1	13

(Actual values: A, +1 = 20% v/v, −1 = 15% v/v; B, +1 = 125 mg, −1 = 75 mg; C, +1 = 125 mg, −1 = 75 mg).