Table 1.
N | LINE-1 | Alu | TP53 | CDKN2A | HIC1 | IL-6 | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean ± SE | p | Mean ± SE | p | Mean ± SE | p | Mean ± SE | p | Mean ± SE | p | Mean ± SE | P | ||
Tobacco smoking status | |||||||||||||
Nonsmokerb | 62 | 76.0±0.4 | 24.9±0.2 | 9.8±0.6 | 5.9±0.4 | 16.6±0.9 | 42.6±1.8 | ||||||
Ex-smoker | 7 | 77.0±1.2 | 0.388 | 25.7±0.6 | 0.174 | 13.0±2.4 | 0.151 | 6.7±1.2 | 0.536 | 25.3±3.8 | 0.012 | 44.2±5.6 | 0.786 |
Smoker | 108 | 75.9±0.3 | 0.903 | 25.0±0.1 | 0.862 | 10.6±0.5 | 0.310 | 6.1±0.3 | 0.723 | 19.9±0.8 | 0.013 | 39.8±1.2 | 0.226 |
Daily cigarette smoking | |||||||||||||
1–9 cigarettes/day | 35 | 76.0±0.5 | 0.981 | 25.0±0.2 | 0.719 | 10.0±0.8 | 0.850 | 6.0±0.5 | 0.953 | 17.6±1.2 | 0.503 | 36.4±1.9 | 0.023 |
≥ 10 cig/day | 73 | 75.9±0.4 | 0.904 | 24.9±0.2 | 0.974 | 11.1±0.7 | 0.170 | 6.2±0.4 | 0.656 | 21.0±1.0 | 0.002 | 41.7±1.6 | 0.719 |
0.900c | 0.985c | 0.149c | 0.637c | 0.001c | 0.961c | ||||||||
Comparison: 1–9 vs ≥ 10 cigarettes/day | 0.930 | 0.713 | 0.279 | 0.718 | 0.029 | 0.029 |
Note. aEstimated from multiple regression models including as independent variables age, gender, smoking status, tobacco consumption, residence and employment, and percent neutrophils in differential blood counts, as appropriated. The adjusted marginal means of the levels of methyaltion were computed at the average values the other covariates.
bReference category.
c p Value for trend between nonsmokers, 1–9 cigarettes/day, and ≥ 10 cigarettes/day.