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. 2013 Oct 31;35(1):69–75. doi: 10.1093/carcin/bgt339

Fig. 3.

Fig. 3.

Interaction between maternal PAH exposure and XRCC1 and NQO1 newborn haplotypes on B[a]P-DNA adducts in cord blood. The significance of newborn XRCC1 haplotype in African-Americans and newborn NQO1 haplotype in Dominicans are shown. Cord blood adducts are higher when African-American newborns harbor XRCC1 haplotype GA (the variant haplotype) and are within the low PAH exposure group, but cord blood adducts are higher when this variant haplotype is harbored and the study participants are within the high PAH exposure group (the interaction coefficient b = −0.92, P = 0.01; n = 113). This same pattern is observed with Dominican newborns with the example of the NQO1 variant haplotype (the interaction coefficient b = −0.51, P = 0.03; n = 106).