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microRNAs influence neuronal regeneration. (A) Severing of an axon usually causes cell death in wildtype neurons (dashed lines), which lost its potential for regeneration through the downregulation of the pluripotency factors Lin 24 and 28 by microRNA let-7. (B)let-7-/- neurons are still able to regenerate destroyed axons, since the pluripotency factors Lin 24 and 28 stay expressed even in post-mitotic cells.
