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let-7 regulates neuronal degeneration. Neurons degrading due to e.g., the consequences of Alzheimer’s disease release the microRNA let-7. Extracellular elevated let-7 molecules are sensed by the Toll-like receptor 7 (TLR 7) which is expressed in cortical neurons. Upon binding the downstream molecule IRAK 4 becomes phosphorylated and induces through yet unidentified signaling molecules cell death.
