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. Author manuscript; available in PMC: 2013 Dec 24.
Published in final edited form as: Gut. 2011 Mar 14;60(9):10.1136/gut.2010.213447. doi: 10.1136/gut.2010.213447

Table 2.

Results of the effective connectivity analysis for the ATD study

PLA
 ATD
Emotional arousal circuits β SE β SE Δ χ 2
omPFC → Amyg −0.23 0.11 0.17 0.08 5.6
Amyg → iACC −0.04 0.17 0.07 0.11 0.2
iACC → rACC −0.15 0.25 0.43 0.15 4.0
rACC → Amyg 0.27 0.31 1.20 0.21 6.0
Amyg → Pons −0.75 0.44 0.90 0.10 6.8
Pons → omPFC −2.44 0.66 −0.61 0.19 6.3

β Values (path coefficients) represent coupling between network regions and demonstrate differences in the effective connectivity between PLA and ATD. The χ2 difference statistic quantifies the differences in connectivity between PLA and ATD. χ2 difference values in bold are significant at p<0.05. Path coefficients were interpreted as significant at p<0.05 and are in bold in the table.

Amyg, amygdala; ATD, acute dietary tryptophan depletion; iACC, infragenual anterior cingulate cortex; omPFC, orbital medial prefrontal cortex; PLA, placebo; rACC, rostral anterior cingulate cortex; Δχ2, χ2 difference statistic.