Table 2.
Results of the effective connectivity analysis for the ATD study
PLA |
ATD |
||||||
---|---|---|---|---|---|---|---|
Emotional arousal circuits | β | SE | β | SE | Δ χ 2 | ||
omPFC | → | Amyg | −0.23 | 0.11 | 0.17 | 0.08 | 5.6 |
Amyg | → | iACC | −0.04 | 0.17 | 0.07 | 0.11 | 0.2 |
iACC | → | rACC | −0.15 | 0.25 | 0.43 | 0.15 | 4.0 |
rACC | → | Amyg | 0.27 | 0.31 | 1.20 | 0.21 | 6.0 |
Amyg | → | Pons | −0.75 | 0.44 | 0.90 | 0.10 | 6.8 |
Pons | → | omPFC | −2.44 | 0.66 | −0.61 | 0.19 | 6.3 |
β Values (path coefficients) represent coupling between network regions and demonstrate differences in the effective connectivity between PLA and ATD. The χ2 difference statistic quantifies the differences in connectivity between PLA and ATD. χ2 difference values in bold are significant at p<0.05. Path coefficients were interpreted as significant at p<0.05 and are in bold in the table.
Amyg, amygdala; ATD, acute dietary tryptophan depletion; iACC, infragenual anterior cingulate cortex; omPFC, orbital medial prefrontal cortex; PLA, placebo; rACC, rostral anterior cingulate cortex; Δχ2, χ2 difference statistic.