Table 2.
Genotype and allele frequencies of the TNF-α gene −1031T>C and −863C>A polymorphisms in the study population.
| TNF-α SNP | Controls (n = 310) | Patients (n = 310) | OR† | 95% CI‡ | P valuea |
|---|---|---|---|---|---|
| −1031T/C | |||||
| TT | 182 (58.71%) | 178 (57.42%) | 1.05 | 0.76–1.45 | 0.8 |
| TC + CC | 128 (41.29%) | 132 (42.58%) | |||
| T | 474 (76.45%) | 462 (74.52%) | 1.11 | 0.85–1.43 | 0.46 |
| C | 146 (23.55%) | 158 (25.48%) | |||
| −863C/A | |||||
| CC | 201 (64.84%) | 92 (29.68%) | 4.37 | 3.11–6.12 | <0.0001* |
| CA + AA | 109 (35.16%) | 218 (70.32%) | |||
| C | 503 (81.13%) | 399 (64.35%) | 2.38 | 1.83–3.08 | <0.0001* |
| A | 117 (18.87%) | 221 (35.65%) |
Values are given in numbers and percentage.
a P value calculated by Chi-square test.
*P value (<0.05) indicates statistical significance.
†Odds ratio.
‡95% confidence intervals.