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. 2013 Dec 9;2013:485213. doi: 10.1155/2013/485213

Figure 6.

Figure 6

Lymphocytic infiltration was improved in the lacrimal glands following immunization with the M3R208–227 peptide. Whole lacrimal glands of NOD/LtJ mice were surgically removed from each mouse and placed in 10% phosphate-buffered formalin for 20 min. After the samples were fixed, embedded, and stained with hematoxylin and eosin (H&E), sections were observed under a microscope. The histological analysis suggested that immunization with M3R208–227 could reduce the lymphocytic infiltration in the lacrimal glands of NOD/LtJ mice. (a) Tissue from a NOD/LtJ mouse immunized with the M3R208–227 peptide. (b) Tissue from a NOD/LtJ mouse immunized with CP. (c) Tissue from a NOD/LtJ mouse immunized with PBS. (d) Mean grade (histological score) of inflammatory lesions in lacrimal glands of NOD/LtJ mouse immunized with the M3R208–227 peptide as compared to the controls (*P < 0.05).