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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: J Immunol. 2013 Dec 2;192(1):300–307. doi: 10.4049/jimmunol.1301436

Figure 1. NOD2 mediates activation of innate immunity by B. pseudomallei.

Figure 1

HEK293 cells transfected with huNOD2 or empty vector and NF-κB-ELAM firefly luciferase and control thymidine kinase Renilla luciferase were stimulated overnight with media, MDP, or heat-killed B. pseudomallei 1026b at various bacteria:cell ratios. Cells were then lysed and NF-κB activation determined by relative light emission (firefly/Renilla luciferases). Data displayed are means ± SD of triplicate conditions normalized to empty vector media values. The data shown are from one of six representative and independent experiments. *, p≤0.05; **, p≤0.01; ***, p≤0.001.