Figure 4.

Effect of treatment with amitriptyline and gabapentin on BALB/c mice with paclitaxel-induced thermal hyperalgesia in a hot-plate test. Percentage change in reaction latency times from baseline values (taken at day 7 after first administration of paclitaxel) at different times after treatment with amitriptyline (10 mg/kg), gabapentin (10 and 30 mg/kg), or their vehicle in a hot-plate test. Each bar represents the mean ± S.E.M of values obtained from 8–16 animals. *P < 0.05 compared to drug vehicle at the same time point after treatment (two-way repeated measures ANOVA followed by Bonferroni test).