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. 2013 Dec 8;2013:240508. doi: 10.1155/2013/240508

Figure 5.

Figure 5

Effect of treatment with E139 on paclitaxel-induced mechanical allodynia in Sprague Dawley rats. (a) Time course of the withdrawal threshold to the dynamic plantar aesthesiometer after administration of paclitaxel 16 mg/kg or its vehicle on two alternate days. Each point represents the mean ± S.E.M of values obtained from 9 animals. *P < 0.05 and **P < 0.01 compared to drug vehicle at the same day after treatment (two-way repeated measures ANOVA followed by Bonferroni test) and ## P < 0.01 compared to pretreatment (PRE) values (one-way ANOVA followed by Dunnett's multiple comparison test). (b) Percentage change in withdrawal threshold from baseline values (taken at day 7 after first administration of paclitaxel) at 2 and 24 h after each treatment with E139 (10 and 20 mg/kg) or its vehicle using a dynamic plantar aesthesiometer. E139 was administered in 4 daily doses. Each bar represents the median values with interquartile range of values obtained from 16 to 17 animals. *P < 0.05 and **P < 0.01 compared to drug vehicle at the same time point after treatment (Kruskal-Wallis test).