. Author manuscript; available in PMC: 2013 Dec 24.

Published in final edited form as: J Med Virol. 2011 Dec;83(12):10.1002/jmv.22226. doi: 10.1002/jmv.22226

TABLE II.

Multivariate Analyses Adjusted for Age, Sex, and Mutations Outside Cytotoxic T-Cell Defined Epitopes

Disease state	OR fold increase per mutation	95% CI	P-value	Other covariates (P-value)
HCC	4.70	1.20–18.37	0.026	Age (<0.001) Mutations outside CDE (0.694)^a Sex (0.551)^a
HBeAg-positive HCC	5.70	1.34–24.22	0.018	Age (0.003) Mutations outside CDE (0.362)^a Sex (0.603)^a
LC	4.29	1.48–12.44	0.007	Age (0.002) Mutations outside CDE (0.550)^a Sex (0.252)^a
HBeAg-positive LC	4.96	1.24–19.77	0.023	Age (0.099)^a Mutations outside CDE (0.543)^a Sex (0.099)^a
HBeAg-negative CHB	30.21	3.24–281.28	0.003	Age (0.711)^a Mutations outside CDE (0.708)^a Sex (0.974)^a
HBeAg negative^b	1.98	1.32–2.96	0.001	Age (0.048) Mutations outside CDE (0.505)^a Sex (0.710)^a

CDE, cytotoxic T-lymphocyte directed epitopes; OR, odds ratio; HBeAg, hepatitis B virus e antigen; HCC, hepatocellular carcinoma; LC, liver cirrhosis; CHB, chronic hepatitis B.

Excluded from the final selected regression model because of lack of significance.

Comparison of all HBeAg-positive versus all HBeAg-negative subjects.