Figure 4.

In vitro antiproliferative effects, showing cytotoxicity of suspension and microemulsion formulations against a (A) A549 cell line and a (B) Lewis cell line at various concentrations for 48 hours (n=6). The dotted line indicates more than 40% inhibition, defined as cytotoxic. Cytotoxicity of bare ME-1 (containing Labrafil® [Gattefossé Co, Ltd, Saint Priest Cedex, France] M 1944CS, Cremophor® [BASF Co, Ltd, Ludwigshafen, Germany] RH40 and PEG400) and bare ME-2 (containing Cremophor RH40 and PEG400) against a (C) A549 cell line and a (D) Lewis cell line at concentrations equivalent to those of the corresponding drug-loaded formulations for 48 hours (n=6). The dotted line indicates less than 20% inhibition, defined as noncytotoxic.

Abbreviations: ME, microemulsion; TME, triterpene-loaded microemulsion.