Figure 4.

Cell type-specific targeting of anti-HER2 aptamer-tagged nanoparticles.

Notes: SK-BR3 (top three rows) and U-87 MG (bottom three rows) cells were incubated with AF (top), HF (middle), or NPAF (bottom), as examined by fluorescence microscopy. Columns on the left show DAPI staining of nuclei, phalloidin staining of actin, fluorescein signal, and a merged picture. The white bar corresponds to 50 μm.

Abbreviations: DAPI, 4′,6-diamidino-2-phenylindole; AF, fluorescein-labeled anti-HER2 aptamer; HF, herceptin; NPAF, nanoparticle–aptamer–fluorescein; HER2, human epidermal growth factor receptor 2.