. Author manuscript; available in PMC: 2014 Jul 1.

Published in final edited form as: Mol Psychiatry. 2013 Sep 3;19(1):99–107. doi: 10.1038/mp.2013.112

Table 1.

Comparison between structural MRI findings of Df16A^+/− mice and structural MRI findings in human subjects with 22q11.2 microdeletion

Brain structure	Df16A^+/− mice	22q11.2 deletion carriers	References	SCZ patients	References
Cerebellum (cortex)	↓	↓	^{24, 36-43}	↓	^44-48
Striatum
Caudate nucleus	↑	↑	^{41, 49-51}		^52-54
Globus pallidus	↑	Calcifications	^{51, 55, 56}	↑	^{53, 57, 58}
Ventricles	↑ (3^rd ventricle)	↑	^{36, 59-61}	↑	^{58, 62, 63}
Amygdala	↓	↓	^{41, 64}	↓	^65-67
Frontal cortex	↓ (sub-regions)	↓	^{50, 59}	↓	^{58, 68}
Pontine nucleus	↓	Decreased volume of pons	³⁸		⁶⁹
Cuneate nucleus	↓	↓ (cuneus)	⁷⁰		^71-73
Corticospinal tracts (pyramids)	↓	None	N/A	↓	^{74, 75}
Lateral olfactory tract	↓	None	N/A	↓ Olfactory bulb	⁷⁶
Posterior commissure	↓	None	N/A	None	N/A
Superior olivary complex	↓	None	N/A	None	N/A
Midbrain	↓	Not significant	³⁸	↓	⁷⁷
Olfactory bulbs	↓	None	N/A	↓ Olfactory bulb	⁷⁶
Hypothalamus	↓	None	N/A	↓	⁷⁸