Table 2.
SNPs with Suggestive Association (P-value ≤ 1 · 10−6) for SBP and DBP in African Americans; Interaction Effect in the Presence of the Main Effect.
| RS number | Chrom | Physical position | MAF | G/I | A1 | A2 | R2 | Trait | SNP main effect | SNP-loop interaction effect | Nearby genes | SNPs per locus | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | SE | Adjusted P-value | Beta | SE | Adjusted P-value | |||||||||||
| rs2811944 | 1 | 23,772,746 | 0.38 | I | T | G | 0.75 | DBP | −1.10 | 0.58 | 5.14 · 10−2 | 11.10 | 1.96 | 1.53 · 10−7 | ID3-MDS2 | 5 |
| rs1633278 | 1 | 157,171,831 | 0.03 | I | C | T | 0.57 | SBP | 4.91 | 3.51 | 2.12 · 10−1 | −82.37 | 13.86 | 5.59 · 10−7 | PYHIN1 | 1 |
| rs1432205 | 2 | 137,612,734 | 0.29 | I | A | C | 0.82 | SBP | −0.48 | 1.09 | 9.01 · 10−1 | −19.55 | 3.88 | 9.46 · 10−7 | THSD7B | 1 |
| rs2729258 | 3 | 577,574 | 0.41 | G | C | G | NA | SBP | 2.59 | 0.90 | 1.73 · 10−2 | −16.27 | 2.85 | 5.71 · 10−7 | CHL1-LOC402123 | 2 |
| rs6811377 | 4 | 41,351,387 | 0.35 | I | A | G | 0.94 | DBP | 1.31 | 0.53 | 1.03 · 10−2 | −9.62 | 1.78 | 5.46 · 10−7 | LIMCH1 | 1 |
| rs535922 | 5 | 103,162,869 | 0.19 | I | C | T | 0.96 | SBP | −1.32 | 1.14 | 2.98 · 10−1 | 21.48 | 3.83 | 1.00 · 10−6 | NUDT12 | 1 |
| rs7702688 | 5 | 103,676,287 | 0.06 | I | C | A | 0.76 | SBP | 2.62 | 2.07 | 2.86 · 10−1 | −55.33 | 8.97 | 2.39 · 10−7 | NUDT12 | 1 |
| rs11744176 | 5 | 152,895,338 | 0.49 | I | T | C | 0.99 | SBP | 0.37 | 0.89 | 5.82 · 10−1 | −16.88 | 3.08 | 6.56 · 10−7 | GRIA1 | 7 |
| rs8040285 | 15 | 89,884,905 | 0.04 | I | C | G | 0.64 | SBP | 2.88 | 3.01 | 4.14 · 10−1 | −77.42 | 13.04 | 5.55 · 10−7 | SV2B-SLCO3A1 | 1 |
Bolded genes represent loci where SNPs are intragenic. A1, allele 1; A2, allele 2; beta, beta coefficient; Chrom, chromosome; DBP, diastolic blood pressure; G/I, genotyped vs. imputed SNP; MAF, minor allele frequency; SBP, systolic blood pressure, SE, standard error of the beta coefficient; SNP, single nucleotide polymorphism.