Table 3.

SNPs with Suggestive Association (P-value ≤ 1 · 10⁻⁵) for SBP and DBP in European Americans; Interaction Effect in the Presence of the Main Effect.

RS number	Chrom	Physical position	MAF	G/I	A1	A2	R2	Trait	SNP main effect			SNP-loop interaction effect			Nearby genes	SNPs per locus
									Beta	SE	Adjusted P-value	Beta	SE	Adjusted P-value
rs3790481	1	68,723,493	0.06	I	C	A	0.83	DBP	0.86	0.96	3.73 · 10−1	−31.62	6.47	2.93 · 10−6	DEPDC1	16
rs6721026	2	200,955,742	0.04	I	A	G	0.79	DBP	−0.23	1.19	8.45 · 10−1	−25.38	5.34	5.29 · 10−6	SPATS2L	2
rs3020401	6	152,324,737	0.35	I	A	G	0.99	SBP	−0.43	0.75	5.64 · 10−1	22.77	3.66	9.51 · 10−6	ESR1	2
rs10764387	10	23,457,184	0.14	I	C	A	0.92	DBP	−0.49	0.61	4.23 · 10−1	13.43	2.84	6.15 · 10−6	PIP4K2A-ARMC3-	17
															MSRB2-PTF1A	17
rs12303986	12	130,314,492	0.03	G	G	A	NA	DBP	−3.04	1.20	1.11 · 10−2	33.16	6.82	3.28 · 10−6	GPR133-SFSWAP	2
rs6012061	20	44,940,236	0.04	I	G	A	0.69	DBP	2.06	1.30	1.12 · 10−1	−27.26	5.66	4.06 · 10−6	RIT2-EYA2	12

Bolded genes represent loci where SNPs are intragenic. A1, allele 1; A2, allele 2; beta, beta coefficient; Chrom, chromosome; DBP, diastolic blood pressure; G/I, genotyped vs. imputed SNP; MAF, minor allele frequency; SBP, systolic blood pressure; SE, standard error of the beta coefficient; SNP, single nucleotide polymorphism.