Figure 3.

Murine homologs of genes twofold regulated in human desmoplastic medulloblastomas (dMB) and classic medulloblastomas (cMB; with respect to normal human cerebella) on the mouse cerebellum developmental background (as described, Fig. 1A). (A) Murine cerebellar development expression spread of 359 mouse genes whose human homologs are twofold regulated in human dMB. Magenta crosses mark genes twofold up-regulated in dMB; green triangles are genes twofold down-regulated in dMB. (B) Histograms of the mouse cerebellar temporal PC1 coordinates of twofold up-regulated (top magenta histogram) and down-regulated (bottom green histogram) genes in human dMB. The number of the 359 genes in each compartment is indicated. The odds ratio (o.r.) and its 95% confidence interval ([left endpoint, right endpoint]), χ², and its associated p value are given. These data indicate a significant and robust association between genes up-regulated in the dMB with the CEMP, as well as down-regulated dMB genes with the CLMP. (C,D) Identical analysis as described in A and B, but for 263 human cMB twofold regulated on a mouse cerebellar development background. Similar conclusions can be drawn as for the dMB concerning the significant and strong correspondence of tumor up-/down-regulated genes and CEMP/CLMP genes.