Table 2.
Allele frequencies.
| Gene | Reference SNP ID | Genotype | Our study (n = 103) | HWE P |
HapmapJPT†
(n = 172) |
P | GeMDBJ‡(MTHFR c.677C>T: n = 2,375 MTHFR c.1298A>C: n = 1,428 SLCO1B1 c.521T>C: n = 1,427) |
P |
|---|---|---|---|---|---|---|---|---|
| MTHFR c.677 C>T | rs1801133 | CC | 32 | 68 | 864 | |||
| CT | 61 | 84 | 1123 | |||||
| TT | 10 | 0.049 | 20 | 0.442 | 388 | 0.885 | ||
|
| ||||||||
| MTHFR c.1298 A>C | rs1801131 | AA | 68 | 112 | 952 | |||
| AC | 31 | 56 | 435 | |||||
| CC | 4 | 0.633 | 4 | 0.924 | 41 | 0.765 | ||
|
| ||||||||
| SLCO1B1 | rs11045879 | TT | 42 | 70 | n.d. | |||
| TC | 43 | 74 | n.d. | |||||
| CC | 18 | 0.495 | 28 | 0.896 | n.d. | n.d. | ||
|
| ||||||||
| SLCO1B1 c.521 T>C | rs4149056 | TT | 73 | 138 | 1048 | |||
| TC | 26 | 30 | 347 | |||||
| CC | 4 | 0.686 | 4 | 0.066 | 32 | 0.408 | ||
Difference of each allele frequency was calculated by χ 2 test.
†NCBI Hapmap JPT: database at National Center of Biotechnology Information (http://www.ncbi.nlm.nih.gov/).
The submitted SNP numbers to NCBI were ss65837366 for MTHFR C677T, ss76885974 for MTHFR A1298C, ss15510724 for SLCO1B1 rs11045879, and ss105439952 for SLCO1B1 T521C.
‡GeMDBJ: Genome Medicine Database of Japan (https://gemdbj.nibio.go.jp/dgdb/index.do).