Table 1.
Prevalence of vitamin D deficiency in unselected cohorts of patients with inflammatory bowel diseases
| Author | Year | Cohort size | Vitamin D status |
|---|---|---|---|
| Driscoll84 | 1982 | 82 CD | 65% of patients had low serum 25(OH)D 25% had levels below 10ng/mL |
| Jahnsen44 | 2002 | 60 CD 60 UC |
27% of CD patients had 25(OH)D levels < 30nmol/L 15% of UC patients had 25(OH)D levels < 30nmol/L |
| Lamb85 | 2002 | 23 UC 11 CD 18 IBS controls |
Mean 25(OH)D was lower in IBD patients (18.7mcg/L) compared to controls (28.5 mcg/L) (p < 0.05) |
| Sentongo27 | 2002 | 112 CD† | 16% of CD patients had vitamin D < 38nmol/L |
| Siffledeen86 | 2003 | 242 CD | 22% had 25(OH)D levels < 40nmol/L 8% had 25(OH)D levels < 25nmol/L |
| Tajika25 | 2004 | 33 CD 15 controls |
27% of CD patients were deficient (25(OH)D < 10ng/mL) compared to 7% of controls |
| McCarthy22 | 2005 | 44 CD | During late-summer, 5% of controls and 18% of CD patients were deficient (<50nmol/L) During late-winter, 25% of controls and 50% of CD patients were deficient |
| Gilman21 | 2006 | 58 CD | 50% were vitamin D deficient during winter (< 50nmol/L) and 19% were deficient during summer |
| Pappa87 | 2006 | 94 CD† 36 UC† |
Prevalence of vitamin D deficiency (25(OH)D < 15ng/mL) was 35% |
| Leslie20 | 2008 | 56 CD 45 UC |
88% had serum 25(OH)D levels below 75nmol/L |
| Kuwabara88 | 2009 | 29 CD 41 UC |
Mean 25(OH) levels were lower in CD patients (11ng/mL) compared to those with UC (20ng/mL) (p < 0.001) |
| Joseph89 | 2009 | 34 CD 34 controls |
25(OH)D levels were lower in CD patients (16ng/mL) compared to controls (23ng/mL) |
| Ulitsky19 | 2011 | 403 CD 101 UC |
50% of patients had 25(OH)D < 30ng/dL, 11% had levels below 10ng/dL |
| Pappa90 | 2011 | 288 CD† 143 UC† 17 IC† |
Vitamin D insufficiency (< 20ng/mL) was seen in 31% of patients with CD and 28% of UC patients |
| Levin17 | 2011 | 70 CD 5 UC 3 IBDU |
19% of patients were deficient in vitamin D (< 51nmol/L) |
| Atia91 | 2011 | 125 IBD | 37% had vitamin D deficiency |
| Suibhne92 | 2012 | 81 CD | 63% of patients with CD were deficient (<50nmol/L) |
| Fu93 | 2012 | 60 UC 40 CD |
39% of the entire cohort had low vitamin D (< 50nmol/L); this was more frequent in 43% of CD and 37% of UC patients |
| Laakso94 | 2012 | 49 UC 28 CD |
30% of patients with CD had levels below 37.5nmol/L compared to 37% of controls |
| Hassan95 | 2013 | 60 IBD | 95% of patients had deficient vitamin D levels (25(OH)D < 30ng/ml) |
| Ananthakrishnan13 | 2013 | 1,763 CD 1,454 UC |
28% had insufficient (20–30ng/mL) and 32% had deficient (< 20ng/mL) levels |
| Alkhouri18 | 2013 | 61 IBD† | 62% of patients had low vitamin D levels compared to 75% of controls |
IBD – inflammatory bowel diseases; CD – Crohn’s disease; UC – ulcerative colitis, IC – indeterminate colitis
†
Pediatric cohorts