Table 6.

Sensitivity Analyses for Endpoint Studies

Comparison groups	k	Effect size r	Between-group Q	p-value
Sample size
All studies
n ≤ 161	51	.18***	3.27	.07
n > 161	50	.12***
Surrogate endpoints
n ≤ 161	11	.12	0.28	.60
n > 161	13	.08*
Subjective clinical endpoints
n ≤ 161	31	.18***	2.48	.12
n > 161	22	.11***
Objective clinical endpoints
n ≤ 161	6	.19	0.19	.67
n > 161	11	.14***
Patient vs. Heterogeneous samples
Patient	51	.12***	0.51	.48
Heterogeneous	50	.15***

Note. P-values for statistical significance of effect size estimates are indicated with asterisks. Between-group heterogeneity statistics and p-values for statistical significance of the difference between groups of studies are shown in the last two columns.

^*p < .05,

^**p < .01,

^***p < .001