Table 3.
Dependent variable | Unadjusted | Multivariable-adjusted* | Additional adjustment for BNP** | |||
---|---|---|---|---|---|---|
| ||||||
β-Coefficient (95% CI) | P-value | β-Coefficient (95% CI) | P-value | β-Coefficient (95% CI) | P-value | |
• Log BNP, pg/ml | 0.46 (0.31, 0.60) | <0.001 | 0.18 (0.03, 0.33) | 0.019 | — | — |
• Tissue Doppler s’ velocity, cm/s | −0.55 (−0.76, −0.34) | <0.001 | −0.38 (−0.62, −0.13) | 0.002 | −0.33 (−0.57, −0.08) | 0.010 |
• Tissue Doppler e’ velocity, cm/s | −0.61 (−0.88, −0.33) | <0.001 | −0.50 (−0.82, −0.18) | 0.002 | −0.49 (−0.81, −0.17) | 0.003 |
• E/e’ ratio | 2.29 (1.37, 3.22) | <0.001 | 1.40 (0.34, 2.44) | 0.010 | 1.09 (−0.02, 2.20) | 0.055 |
• Isovolumic relaxation time, ms | 7.75 (5.42, 10.09) | <0.001 | 4.91 (2.20, 7.62) | <0.001 | 3.69 (0.92, 6.45) | 0.009 |
• LV mass index, g/m2 | 10.39 (6.90, 13.87) | <0.001 | 5.95 (1.74, 10.15) | 0.006 | 4.63 (0.18, 9.07) | 0.041 |
• TAPSE, cm | −0.16 (−0.22, −0.10) | <0.001 | −0.13 (−0.20, −0.06) | 0.001 | −0.09 (−0.17, −0.01) | 0.023 |
• RV wall thickness, mm/m2 | 0.15 (0.09, 0.22) | <0.001 | 0.11 (0.04, 0.17) | 0.001 | 0.08 (0.01, 0.14) | 0.021 |
Multivariable model adjusted for age, sex, body-mass index, diabetes mellitus, atrial fibrillation, coronary artery disease, estimated glomerular filtration rate, amiodarone use, diuretic use, QRS interval, and QTc interval
Includes all covariates of the multivariable model plus log BNP
BNP, B-type natriuretic peptide; TAPSE, tricuspid annular plane systolic excursion; RV, right ventricular; LV, left ventricular; CI, confidence interval.