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. 2000 Dec 15;106(12):1489–1499. doi: 10.1172/JCI10498

Figure 4.

Figure 4

(a) Concentration-dependent clearance of Aβ1-40 from mouse brain. Clearance via BBB transport (filled circles) is shown separately from clearance via ISF bulk flow (open circles). Clearance was determined 30 minutes after simultaneous microinjection of 125I-Aβ1-40 at increasing concentrations (0.05–120 nM) along with [14C]inulin into the caudate nucleus. (b) Effects of anti–LRP-1 Ab R777 (60 μg/ml), RAP (0.2 and 5 μM), anti-α2M Ab (20 μg/ml), and anti–LRP-2 Ab Rb6286 (60 μg/ml) on brain clearance of 125I-Aβ1-40 at 12 nM, determined 30 minutes after simultaneous microinjection of 125I-Aβ1-40 and [14C]inulin. (c) Effects of anti–LRP-1 Ab R777 (60 μg/ml), anti-RAGE Ab (60 μg/ml), fucoidin (100 μg/ml), and 2-amino-bicyclo[2.2.1]heptane-2-carboxylic acid (BCH; 10 mM) on brain clearance of 125I-Aβ1-40 at a higher load of 60 nM, determined 30 minutes after simultaneous microinjection of 125I-Aβ1-40 and [14C]inulin. Mean ± SD of three to four animals. AP < 0.05; NS, not significant.