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(a) Effect of apoE genotype and age on brain clearance of 125I-Aβ1-40. Brain clearance of 125I-Aβ1-40 in 2-month-old and 9-month-old wild-type mice and apoE KO mice studied at the lower load of 12 nM 125I-Aβ1-40 (a) and a higher load of 60 nM (b). In all studies, 125I-Aβ1-40 and [14C]inulin were injected simultaneously, and clearance was determined after 30 minutes. Mean ± SD of three to four animals. AP < 0.05; NS, not significant compared with 2-month-old wild-type mice.
