Apoptosis in A549 and Hela cells induced by oxytetracycline, propafenone and metamizole. (A) Morphology image of apoptosis. Cells were treated with the drugs or 0.1% DMSO (control) for 48 h, and then were stained with Hoechst 33258. (a-d) A549; (e-i) Hela; (a,e) Control; (b) Oxytetracycline 0.1 g/L; (c) Propafenone 0.02 g/L; (d) Metamizole 0.1 g/L; (f) Oxytetracycline 0.20 g/L; (g) Metamizole 0.20 g/L; (h,i) Ppropafenone 0.012 and 0.014 g/L, respectively; (B) Apoptosis rate of Hela cells corresponding to e-i in A. Data are x̄±s from three independent experiments. *, P<0.05 vs. control.