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. 2013 Dec 26;4:471. doi: 10.3389/fimmu.2013.00471

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Copyright © 2013 Simeonovic, Ziolkowski, Wu, Choong, Freeman and Parish.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Autoimmune T1D in NOD/Lt mice is characterized by cell surface expression of heparanase on insulitis leukocytes. Histology (A) and immunohistochemistry (B) of a pancreatic islet in a NOD/Lt female mouse at the time of T1D onset shows islet infiltration by destructive heparanase (Hpse)-expressing insulitis leukocytes (B) localized particularly at the insulitis-islet interface, a process which leads to loss of beta cell HS and beta cell death. (A) hematoxylin and eosin; (B) HP130 anti-heparanase mAb. Ins, insulitis mononuclear cells; DI, damaged islet tissue; Hpse, heparanase.