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In MS patients receiving immunomodulatory treatment, we found the number of days since onset of last relapse to be a significant predictor of permeability in MS non-enhancing lesions (A), and periventricular normal appearing white matter (B). In the untreated group we found no such relation. Data points = mean value for each subject. Continuous line = logarithmic fit line; y = a − b∗log(x). R sq = R2. IFN-beta = interferon beta. GA = glatiramer acetate.
