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. 2013 Dec 26;4:384. doi: 10.3389/fphys.2013.00384

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Copyright © 2013 Sureshbabu and Bhandari.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagrammatic representation showing the molecular events of Parkin/PINK1 mediated mitophagy process. Low Δψm suppresses the activity of TOM complex and leads to the accumulation of PINK1. This is followed by translocation of Parkin from cytoplasm to mitochondria where it is activated by PINK1. Subsequently, Parkin ubiquinates OMM proteins including but not limited to MFN1, MFN2, VDAC, and MIRO-1. These ubquitinated proteins are then recognized by autophagy proteins P62 and LC3 II where subsequent degradation of damaged mitochondria occurs within the mitochondrial membrane; IMS, Inter mitochondrial space; OMM, Outer mitochondrial membrane. (For additional details and abbreviations, please see text).