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A, isometric tension recording of spontaneous colonic migrating motor complexes (CMMCs) occurring in a Tph1−/− colon. B, hexamethonium (100 μm) blocked spontaneous CMMC activity in a Tph1−/− colon. C, spontaneous CMMCs occurring in a Tph1−/− colon. D, addition of 15% colonic elongation (to activate the occult reflex) reduced spontaneous CMMCs in the Tph1−/− mouse.
