Figure 7. Colonic migrating motor complexes (CMMCs) evoked by activation of reflexes in Tph1−/− mice.
A, CMMC evoked by balloon distension in Tph1+/+ and Tph1−/− colon. B, plot summarizing CMMCs evoked by balloon distension in Tph1+/+ and Tph1−/− mice as a percentage of spontaneous CMMC area in the Tph1+/+ colon. Dotted line indicates oral to anal CMMC propagation in Tph1+/+ but not in Tph1−/− mice. C, mucosal stimulation (four brush strokes applied anally) evoked a CMMC in Tph1+/+ colon, but not in Tph1−/− colon. D, plot summarizing CMMC area evoked by oral and anal mucosal stimulation in Tph1+/+ and Tph1−/− colon.