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. 2013 Sep 16;591(Pt 23):5977–5998. doi: 10.1113/jphysiol.2013.262022

Figure 7. FCCP sensitivity of TASK-like channels in type-1 cells.

Figure 7

A, B, representative single-channel recording showing the reversibility of inhibition of background channel activity by 1 μm FCCP in control type-1 cells. Recording conditions were as for hypoxia and cyanide experiments. C, superimposition of all-points histograms derived from recordings made during superfusion with control and FCCP Tyrode solutions. D, comparison of relative background channel activity in cell-attached patches during control and FCCP exposure (n= 13 patches). E, F, single-channel recording from a Task-1−/− type-1 cell showing the reversibility of inhibition of channel activity by FCCP. G, superimposed histograms constructed from Task-1−/− data obtained during control and FCCP Tyrode superfusion. H, relative channel activity for Task-1−/− during control and FCCP exposure (n= 14 patches). I, J, Task-3−/− single-channel activity inhibition by FCCP. K, superimposition of all-points histograms created from Task-3−/− type-1 cell control and FCCP recordings. L, comparison of relative channel activity in Task-3−/− cells during FCCP exposure (n= 8 patches).